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sPAP
mPAP
Info
… Conclusions Pre-clinical PH is associated with an increase in miR10b-5p expression and
decrease in its targets CADM1 and APAF1. miR10b-5p inhibition rescues experimental PH …
(Clark, V. R., et al. "MicroRNA10b-5p Inhibition as a Novel Therapeutic Strategy for Treatment of Pre-Existing Pulmonary Hypertension in Rats." D25. O BRAVE NEW WORLD! OMICS, SYSTEM BIOLOGY, AND NEW MOLECULAR MECHANISMS OF PULMONARY HYPERTENSION. American Thoracic Society, 2020. A6357-A6357.)
NCBI Gene Summary for CADM1 Gene
- Enables signaling receptor binding activity. Involved in several processes, including cell recognition; positive regulation of cytokine production; and susceptibility to natural killer cell mediated cytotoxicity. Located in plasma membrane. Implicated in breast carcinoma and prostate cancer. Biomarker of cervix uteri carcinoma in situ. [provided by Alliance of Genome Resources, Apr 2022]
GeneCards Summary for CADM1 Gene
CADM1 (Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with CADM1 include Cervix Uteri Carcinoma In Situ and Parapsoriasis. Among its related pathways are Cell junction organization and Splicing factor NOVA regulated synaptic proteins. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and PDZ domain binding. An important paralog of this gene is CADM2.